Mid Candidature Review: Sources, fate and exposure to organophosphate flame retardants
Abstract: Organophosphate flame retardants (OPFRs) are widely used as flame retardants in various consumer and industrial products, such as plastics, electronic equipment, furniture, textiles, and building materials. The production volume of OPFRs is expected to increase due to production and use restrictions placed on brominated flame retardants, and some OPFRs are known to be relatively persistent, mutagenic, carcinogenic, and neurotoxic. However, data on environmental persistence and toxicity of OPFRs are limited. The knowledge gap leaves large uncertainties in the fate in both environment and human body.
The aim of my project is to generate information on the occurrence of OPFRs in indoor environment, and to provide information on human exposure to OPFRs. Two chapters will assess the levels and sources of OPFRs in indoor environment. In the first chapter, a new analytic method of OPFR in dust samples will be developed and validated. Then, OPFR levels in indoor air and dust from different microenvironments will be assessed. The following chapter is proposed to assess the fate of OPFRs in human, in which OPFR metabolites in urine samples collected from Australian/New Zealand population would be assessed. Another chapter is proposed to estimate human intake and pathways of OPFRs. Together, the outcome of this project would provide some information on the source of OPFRs in environment, and their fate and exposure to human beings.
Mid Candidature Review Panel
Supervisors: Prof Jochen Mueller and Dr Phong Thai
Chair: Prof Kevin Thomas
Readers: Dr Leisa-Maree Toms and Prof Darryl Hawker