Understanding bacterial-nanoparticle interactions at the molecular level
Nanoindustry is one of the fastest growing industries in the history of mankind and has been referred to as the biggest engineering innovation since the Industrial Revolution. Nanoparticles (NPs) have unique physical, chemical and biological properties and have been widely applied in industrial and household sectors. However, the intensive use of nanoparticles can pose serious environmental contaminations and public health risks. Previous studies indicated that the interactions between nanoparticles and microorganisms are often toxic. However, there is a considerable paucity of data for the underlying molecular mechanisms.
This project will reveal the interactions that occur between nanoparticles and bacteria with the objective of identifying inhibitory and biocidal mechanisms and find those undiscovered potential effects through a series of advanced molecular and bioscience methods, including genome- wide RNA sequencing. The findings will be critical for any prediction of their immediate and long-term risks for humans and ecosystems, and fundamental to improve the control of this emerging environmental challenge, but still remains a major knowledge gap.
Dr. Jianhua Guo