Toxicological effects of T-2 toxin and Deoxynivalenol on bone development and their roles in Kashin-Beck disease

T‐2 toxin and deoxynivalenol (DON) are representatives of type A and type B trichothecenes, respectively. They are prevalent mycotoxin contaminants in the food and feed stuffs worldwide. Meanwhile, they are considerable risk factors for Kashin‐Beck disease, a chronic endemic osteochondropathy in China. In this representation, the associations of T-2 toxin and DON with Kashin‐Beck disease will be reviewed. And the potential toxicological effects, interactions and mechanisms will be explored in human C‐28/I2 and rat primary chondrocytes, and newborn rat metacarpal and metatarsal bones. It helps to understand how exposure to T‐2 toxin and DON affect bone development in the natural environment, and assists in the assessment of potential risk.

Xialu Lin is a PhD candidate in Health Science Center, Xi'an Jiaotong University, and presently a visiting research student at QAEHS.