Investigating human toxicokinetics for human biomonitoring-based risk assessments

Investigating human toxicokinetics for human biomonitoring-based risk assessments - Katharina Ebert

Human Biomonitoring (HBM) refers to the analysis of xenobiotics or their metabolites in human biological matrices such as blood or urine, encompassing all exposure routes and reflecting the actual individual exposure. In order to perform reliable and informative HBM-based exposure and risk assessments, the prior investigation of a substance’s toxicokinetics is essential. Human toxicokinetics studies can be used to derive urinary excretion fractions (F_UE), which allow a back-calculation of external doses based on the measured biomarker concentrations in matrix, thereby enabling quantitative exposure assessments in population studies.

This presentation will give a brief repetition of the basic principles of HBM and explain the workflow of human toxicokinetics studies using a real-life example.