Evaluating the Permeability of the Blood-Brain Barrier to Plastic-Associated Chemicals

Organophosphate flame retardants (OPFRs) are plastic additives widely used in consumer products and have been detected in air, household dust, and drinking water. Biomonitoring studies confirm continuous human exposure, raising concerns about their potential negative effects on human health, particularly their neurotoxicity. However, there is currently limited evidence on whether OPFRs can reach the central nervous system, as well as which compounds are most likely to do so.

This PhD project focuses on the development and application of an in vitro model to assess the permeability of the blood-brain barrier for different OPFRs, with the aim of providing experimental data on their potential access to the central nervous system and contributing to a better understanding of their neurotoxic risk.

Please note, this is a Student Progress Review presentation by Marta Lopez