Collaboration on Endocrine Disrupting Chemicals between RCSI Bahrain and The University of Queensland

A major focus has been on phthalate exposure with our publications showing an inverse correlation of phthalates with vitamin D in women, higher MnBP levels in diabetes, and increased low molecular weight phthalates (MiBP and MnBP) during the time-restricted fasting of Ramadan. Waste water analysis before, during and after Ramadan showed weekly increases in MMP on Saturdays with a marked increased trajectory of MMP over the period. Phthalate contribution to the increased incidence of vulval cancer has been investigated, looking at phthalates in underwear compared to thigh and vulval skin with in vitro studies on potential mechanisms.  The androgenic effects of phthalates have been investigated using SZ95 cells as a model for acne, and direct effects on the androgen receptor (AR) using an AR-luciferase reporting cell line. Evidence that parent phthalates may bioaccumulate will be presented. Results of the additional studies published on perfluorinated alkyl acids, polychlorinated biphenyls, brominated flame retardants and organochlorine pesticides will be detailed. This collaboration has resulted in 11 Q1 publications, another currently in revision, and a further 5 in preparation.

Professor Stephen Atkin has served as Head of the School of Postgraduate Studies and Research at the Royal College of Surgeons of Ireland in Bahrain since August 2019. Previously, he was a Professor of Medicine at the Weill Cornell Medical College in Qatar (2014 – 2019), and prior to that he was Professor of Medicine and Head of Diabetes and Endocrinology at the Hull York Medical School, UK (2006 – 2014). He has an established international reputation in diabetes, metabolic disorders and obesity research, encompassing polycystic ovary syndrome and metabolic syndrome, with a strong collaboration with the University of Queensland on clinical effects of Endocrine Disrupting Chemicals. Professor Atkin has a specific interest in translational medicine, encompassing both clinical and laboratory work and he has authored or co-authored more than 500 peer-reviewed articles, as well as patents and international guidelines.