Chemical Contaminants in the Human Brain and Links to Neurodegenerative Diseases

Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic chemicals known for their highly useful properties, including water and oil repellency, and resistance to high temperatures, leading to their extensive use across various industrial sectors and consumer products. PFAS have been widely detected in the environment, biota, and humans. Despite many studies indicating the adverse effects of PFAS exposure on human health, our understanding of the effects of PFAS exposure in relation to brain function remains highly limited. This PhD project aims to enhance our understanding of PFAS accumulation in the human brain and its potential links to neurodegenerative diseases, particularly Motor Neuron Disease (MND) and Parkinson’s Disease (PD). Additionally, this research will identify geographical hotspots for PD in Australia, investigating potential factors contributing to an elevated incidence of PD in these areas. This study also will explore the role of paraquat, a widely utilized herbicide, in relation to PD by analysing paraquat concentrations in PD patients. This study will provide new insights into PFAS accumulation in the human brain and the contribution of chemical exposure to the development of neurodegenerative diseases.

 Please note this a Student Progress Review presentation by Marina Suzuki.